What is gMG?
Generalized myasthenia gravis (gMG) is a rare autoimmune disease that impacts the neuromuscular system
It is estimated that more than 71,000 people in the United States are living with anti-acetylcholine receptor (AChR) antibody-positive gMG.
Despite available treatments, 50% of the people in a study reported still experiencing gMG symptoms that limited their everyday life.

Despite available treatments, 50% of the people in a study reported still experiencing gMG symptoms that limited their everyday life.
In gMG, a part of your immune system called complement disrupts signals between your muscles and nerves
Normally, the complement system helps your body fight off infections. But when you have gMG, complement causes worsening damage to the neuromuscular junction, the area where the nerves and muscles meet.
How can gMG damage muscles?
Explore ULTOMIRIS in the BodyStep 1:
Anti-AChR antibodies block your muscle receptors. Your body identifies this as a threat and responds by activating the complement system.
Step 2:
The complement system, activated in part by a key protein called C5, contributes to damage on the surface of your muscles.
Step 3:
Muscle cell damage prevents your receptors from receiving nerve signals, causing the gMG symptoms you may experience.
Muscle damage caused by gMG can make daily activities and physical functions challenging

Vision
For many patients, double vision and drooping eyelids are the first symptoms of gMG. Vision problems may impact your ability to drive, read, or watch TV.

Breathing
When gMG damages the muscles of your diaphragm, you may experience trouble breathing. Breathing impairment may impact your ability to speak or move around.

Speech
gMG can make it hard to speak or may cause you to slur your words. Speech difficulties may make it tough for those around you to understand what you are saying.

Eating
Muscle weakness associated with gMG can make it harder to swallow or hold your head up. Eating difficulties may impact your ability to go out to eat or even eat alone.

Mobility
Since gMG damages your muscles, you may experience weakness in your arms and/or legs. Muscle weakness can make personal grooming, household chores, and traveling more difficult to do.
Use this questionnaire to assess your gMG symptoms. Then, talk to your doctor about your results
Download the gMG symptom questionnaireReceive information & updates
