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Ready to make the switch?

You may have started treatment with SOLIRIS (eculizumab)

For many people living with atypical-HUS, the first medication that a hospital or their doctor will start them on is called SOLIRIS. This is a medication that works similarly to ULTOMIRIS but is generally infused every 2 weeks.

If you are switching your treatment from SOLIRIS to ULTOMIRIS, you should receive your starting dose of ULTOMIRIS 2 weeks after your last dose of SOLIRIS.

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Many people switch to ULTOMIRIS

Both ULTOMIRIS and SOLIRIS work to remove C5 from the bloodstream and help prevent the uncontrolled complement activity that can cause TMA. But only ULTOMIRIS provides the freedom of long-acting C5 control.

See how ULTOMIRIS works

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ULTOMIRIS is designed to last longer

The scientists behind SOLIRIS were able to update the medicine and create ULTOMIRIS, a treatment that is recycled and reused by the body more effectively.* This improvement is what lets ULTOMIRIS stay in the body up to 4 times longer—and what makes it the first and only long-acting treatment for atypical-HUS.

ULTOMIRIS is engineered for fewer infusions

Because ULTOMIRIS can keep you protected longer, you can take advantage of needing fewer infusions. That’s why so many people living with atypical-HUS are choosing to switch their treatment to long-acting ULTOMIRIS.

Switch to fewer infusions

1 year on SOLIRISULTOMIRIS

SOLIRIS

Adults and children

26 infusions per year

(after starting dose)

ULTOMIRIS

Most people

7 infusions per year

(after starting dose)


or 13 infusions
for children under
44 lb (20 kg)

See SOLIRIS Make the Switch
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With ULTOMIRIS, infusions may take less than 1 hour for most patients.

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Ready to talk to your healthcare team about ULTOMIRIS?

Your healthcare team is always your best source of information about your care—
but it is important that they understand your needs too.


Here are a few questions to get the conversation started:

Could I switch to ULTOMIRIS?

Is there anything I need to know before starting ULTOMIRIS?

Can we make a plan for my first ULTOMIRIS infusion?

I wanted to spend less time feeling like a patient and more time being a person. ULTOMIRIS helped me with that.”

Andrea, Michigan
Hear Me Speak

Actor portrayal. Each person’s results with ULTOMIRIS may vary.

Quotes are composites based on actual experiences of real people living with atypical-HUS.

Still have questions?

We’ve answered some Frequently Asked Questions about switching to ULTOMIRIS.


Download FAQs

ULTOMIRIS may cost less than SOLIRIS

For most people, ULTOMIRIS is less expensive than SOLIRIS. Some pay as low as $0 in out-of-pocket costs.§

See How OneSource Can
Help You Save

*Based on preclinical data.

Two weeks after your last dose of SOLIRIS, you will receive a starting dose of ULTOMIRIS. Then maintenance doses are administered (or infused) every 8 weeks for most people and every 4 weeks for children under 44 pounds (20 kilograms).

After each infusion, you may be monitored for at least 1 hour for infusion-related reactions.

§The Alexion OneSource™ CoPay Program is not valid for costs eligible to be reimbursed by government insurance programs or other federal or state programs (including any state prescription drug assistance programs), including Medicaid, Medicare (including Medicare Part D), Medicare Advantage Plans, Medigap, Veterans Affairs, Department of Defense, or TRICARE. People residing in Massachusetts, Michigan, Minnesota, and Rhode Island are eligible for assistance with medication costs but are not eligible for assistance with infusion costs.

Next: Learn more about ULTOMIRIS infusions

FDA approved 100 mg/mL formulation: get the details

IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING

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What is the most important information I should know about ULTOMIRIS?

ULTOMIRIS is a medicine that affects your immune system and can lower the ability of your immune system to fight infections.

  • ULTOMIRIS increases your chance of getting serious and life-threatening meningococcal infections that may quickly become life-threatening and cause death if not recognized and treated early.
  1. You must receive meningococcal vaccines at least 2 weeks before your first dose of ULTOMIRIS if you are not vaccinated.
  2. If your healthcare provider decided that urgent treatment with ULTOMIRIS is needed, you should receive meningococcal vaccination as soon as possible.
  3. If you have not been vaccinated and ULTOMIRIS therapy must be initiated immediately, you should also receive 2 weeks of antibiotics with your vaccinations.
  4. If you had a meningococcal vaccine in the past, you might need additional vaccination. Your healthcare provider will decide if you need additional vaccination.
  5. Meningococcal vaccines reduce but do not prevent all meningococcal infections. Call your healthcare provider or get emergency medical care right away if you get any of these signs and symptoms of a meningococcal infection: headache with nausea or vomiting, headache and fever, headache with a stiff neck or stiff back, fever, fever and a rash, confusion, muscle aches with flu-like symptoms and eyes sensitive to light.

Your healthcare provider will give you a Patient Safety Card about the risk of meningococcal infection. Carry it with you at all times during treatment and for 8 months after your last ULTOMIRIS dose. It is important to show this card to any healthcare provider or nurse to help them diagnose and treat you quickly.

ULTOMIRIS is only available through a program called the ULTOMIRIS REMS. Before you can receive ULTOMIRIS, your healthcare provider must: enroll in the ULTOMIRIS REMS program; counsel you about the risk of meningococcal infection; give you information and a Patient Safety Card about the symptoms and your risk of meningococcal infection (as discussed above); and make sure that you are vaccinated with a meningococcal vaccine, and if needed, get revaccinated with the meningococcal vaccine. Ask your healthcare provider if you are not sure if you need to be revaccinated.

ULTOMIRIS may also increase the risk of other types of serious infections. Make sure your child receives vaccinations against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) if treated with ULTOMIRIS. Call your healthcare provider right away if you have any new signs or symptoms of infection.

Who should not receive ULTOMIRIS?

Do not receive ULTOMIRIS if you have a meningococcal infection or have not been vaccinated against meningococcal infection unless your healthcare provider decides that urgent treatment with ULTOMIRIS is needed.

Before you receive ULTOMIRIS, tell your healthcare provider about all of your medical conditions, including if you: have an infection or fever, are pregnant or plan to become pregnant, and are breastfeeding or plan to breastfeed. It is not known if ULTOMIRIS will harm your unborn baby or if it passes into your breast milk. You should not breastfeed during treatment and for 8 months after your final dose of ULTOMIRIS.

Tell your healthcare provider about all the vaccines you receive and medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements which could affect your treatment.

If you have aHUS, your healthcare provider will need to monitor you closely for at least 12 months after stopping treatment for signs of worsening aHUS or problems related to a type of abnormal clotting and breakdown of your red blood cells called thrombotic microangiopathy (TMA). Symptoms or problems that can happen with TMA may include: confusion or loss of consciousness, seizures, chest pain (angina), difficulty breathing and blood clots or stroke.

ULTOMIRIS can cause serious side effects including allergic reactions to acrylic adhesive. Allergic reactions to the acrylic adhesive may happen with your subcutaneous ULTOMIRIS treatment. If you have an allergic reaction during the delivery of subcutaneous ULTOMIRIS, remove the on-body injector and get medical help right away. Your healthcare provider may treat you with medicines to help prevent or treat allergic reaction symptoms as needed.

What are the possible side effects of ULTOMIRIS?

ULTOMIRIS can cause serious side effects including infusion-related reactions. Symptoms of an infusion-related reaction with ULTOMIRIS may include lower back pain, tiredness, feeling faint, discomfort in your arms or legs, bad taste, or drowsiness. Stop treatment of ULTOMIRIS and tell your healthcare provider or nurse right away if you develop these symptoms, or any other symptoms during your ULTOMIRIS infusion that may mean you are having a serious infusion reaction, including: chest pain, trouble breathing or shortness of breath, swelling of your face, tongue, or throat, and feel faint or pass out.

The most common side effects of ULTOMIRIS in people treated for aHUS are upper respiratory tract infection, diarrhea, nausea, vomiting, headache, high blood pressure and fever.

The most common side effects of subcutaneous administration of ULTOMIRIS in adults treated for aHUS are local injection site reactions.

Tell your healthcare provider about any side effect that bothers you or that does not go away. These are not all the possible side effects of ULTOMIRIS. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider right away if you miss an ULTOMIRIS infusion or for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Instructions for Use that comes with subcutaneous ULTOMIRIS for instructions about the right way to prepare and give your subcutaneous ULTOMIRIS injections through an on-body injector.

INDICATION

What is ULTOMIRIS?

ULTOMIRIS is a prescription medicine used to treat:

  • adults and children 1 month of age and older with a disease called atypical Hemolytic Uremic Syndrome (aHUS). ULTOMIRIS is not used in treating people with Shiga toxin E. coli related hemolytic uremic syndrome (STEC-HUS).
  • adults with aHUS when administered subcutaneously (under your skin).

It is not known if ULTOMIRIS is safe and effective in children younger than 1 month of age.

Subcutaneous administration of ULTOMIRIS has not been evaluated and is not approved for use in children.

Please see the accompanying full Prescribing Information and Medication Guide for ULTOMIRIS, including Boxed WARNING regarding serious and life-threatening meningococcal infections/sepsis. Please see the accompanying Instructions for Use for the ULTOMIRIS On Body Delivery System.